| Description | Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic. |
| In vitro | 与未处理的小鸡相比,225 mg/L Apramycin完全抑制了死亡率,并明显减少了沙门氏菌的排泄. |
| In vivo | 1/4 MIC Apramycin在培养基中降低测试菌株的生长速率,并且引起高达5小时的抗生素后效应。Apramycin抑制A. pleuropneumoniae FMV 87-682,MIC50为8 mg/l。Apramycin明显降低A. pleuropneumoniae的溶血活性,并且影响该分离株的和一种P. multocida分离株(类型A) 的囊膜物质生产。由亮氨酸、异亮氨酸和丝氨酸的结合检测发现,Apramycin诱导翻译错误,尽管这种作用仅发生于有限的范围,来自用poly（U）编程的大肠杆菌的无细胞系统中。 |
| Synonyms | Nebramycin II, Ai3-29795, 硫酸安普霉素, 硫酸阿布拉霉素 |
| molecular weight | 637.66 |
| Molecular formula | C21H43N5O15S |
| CAS | 65710-07-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 10 mM DMSO: Insoluble |
| References | 1. Jensen VF, et al. J Antimicrob Chemother, 2006, 58(1), 101-107. 2. Diarra MS, et al. Int J Antimicrob Agents, 1999, 12(3), 229-237. 3. Kamei C, et al. Immunopharmacol Immunotoxicol, 1992, 14(1-2), 191-205. 4. Tacconi G, et al. Avian Pathol, 1987, 16(2), 319-326. |