| Description | Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism. |
| Synonyms | 落叶松蕈酸, Agaricinic Acid |
| molecular weight | 416.55 |
| Molecular formula | C22H40O7 |
| CAS | 666-99-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.17 mg/mL (10 mM) |
| References | 1. García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5(4):272-81. 2. Edmundo Chávez, Buelna-Chontal M , Arturo Macías-López, et al. Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress[J]. Biochemistry Research International, 2020, 2020(3):1-8. |