| Description | 7-Hydroxyisoflavone against Enterovirus 71 in vitro. |
| In vitro | 7-hydroxyisoflavone was active against EV71.?7-Hydroxyisoflavone exhibited strong antiviral activity against three different EV71 strains.?The 50% inhibitory concentration range was between 3.25 and 4.92 μM by cytopathic effect assay.?7-Hydroxyisoflavone could reduce EV71 viral RNA and protein synthesis in a dose-dependent manner.?Time course study showed that treatment of Vero cells with 7-hydroxyisoflavone at indicated times after EV71 inoculation (0-6 h) resulted in significant antiviral activity[1]. |
| molecular weight | 238.24 |
| Molecular formula | C15H10O3 |
| CAS | 13057-72-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (104.94 mM) |
| References | 1. Wang H Q , Meng S , Li Z R , et al. The antiviral effect of 7-hydroxyisoflavone against Enterovirus 71\r, in vitro[J]. Journal of Asian Natural Products Research, 2013, 15(4):382-389. 2. Miao J , Cui H , Jin J , et al. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging[J]. Chem Commun, 2015, 51(5):881-884. |