| Description | 1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells. |
| In vitro | 1-Methylxanthine 展现了与其他天然发生的甲基黄嘌呤类似的活性。与咖啡因和Theobromine 不同，3-甲基黄嘌呤和1-Methylxanthine 在植物中含量不高。1-Methylxanthine （3 mM；作用30分钟）增强了辐射诱导的克隆形成和凋亡细胞死亡（携带野生型蛋白53千道尔顿(p53)的RKO人类结直肠癌细胞）。 |
| molecular weight | 166.14 |
| Molecular formula | C6H6N4O2 |
| CAS | 6136-37-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 20 mg/ml (120.38 mM) |
| References | 1. Algharrawi KH, et al. Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microb Cell Fact. 2015 Dec 21;14:203. 2. Youn H, et al. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85(2):167-74. |