α-Conotoxin M I_product_DataBase

Bioactivity	α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].
Target	mAChR; α1β1γδ nAChR
Invitro	α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2].
Name	α-Conotoxin M I
CAS	88217-10-1
Shortening	GRCCHPACGKNYSC-NH2 (Disulfide bridge:Cys3-Cys8;Cys4-Cys14)
Formula	C58H88N22O17S4
Molar Mass	1493.72
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kulak JM, et al. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997 Jul 15;17(14):5263-70. [2]. Bren N, et al. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. J Biol Chem. 2000 Apr 28;275(17):12692-700.

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