| Bioactivity | COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1]. |
| Invitro | COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively[1].COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)[1].COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity[1]. |
| Name | AChE/HDAC-IN-1 |
| CAS | 2414053-06-6 |
| Formula | C26H27ClN4O3 |
| Molar Mass | 478.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721. |
AChE/HDAC-IN-1
CAS: 2414053-06-6 F: C26H27ClN4O3 W: 478.97
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 ex
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