| Bioactivity | p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. | ||||||||||||
| Target | Ki: 32.6 μM (TPH) | ||||||||||||
| Invitro | p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1]. | ||||||||||||
| In Vivo | p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1]. Animal Model: | ||||||||||||
| Name | p-Ethynylphenylalanine | ||||||||||||
| CAS | 278605-15-5 | ||||||||||||
| Formula | C11H11NO2 | ||||||||||||
| Molar Mass | 189.21 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. |
p-Ethynylphenylalanine
CAS: 278605-15-5 F: C11H11NO2 W: 189.21
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of trypt
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.