| Bioactivity | VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1]. | |||||||||
| Target | EC50: 10.7 μM (HssRS)pEC50: 4.97 (HssRS) | |||||||||
| Invitro | VU0420373 (compound 2e) has an IC50 of >60 μMfor Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1]. | |||||||||
| Name | VU0420373 | |||||||||
| CAS | 38376-29-3 | |||||||||
| Formula | C15H11FN2O | |||||||||
| Molar Mass | 254.26 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Brendan F Dutter, et al. Decoupling Activation of Heme Biosynthesis From Anaerobic Toxicity in a Molecule Active in Staphylococcus Aureus. ACS Chem Biol. 2016 May 20;11(5):1354-61. |