| Bioactivity | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. | ||||||||||||
| Target | EC50: 0.4 μM (glucocerebrosidase) | ||||||||||||
| Invitro | ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1]. | ||||||||||||
| Name | ML198 | ||||||||||||
| CAS | 1380716-06-2 | ||||||||||||
| Formula | C17H14N4O | ||||||||||||
| Molar Mass | 290.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. |