| Bioactivity | Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim[1]. | ||||||||||||
| Invitro | Trimethoprim 3-oxide is the primary metabolite of trimethoprim[1].Trimethoprim 3-oxide (3-NO-TMP) is converted from trimethoprim by CYP1A1 and CYP1B1 with highest rates in human liver microsomes (HLMs). The CYP1A inhibitor α-Naphthoflavone inhibits Trimethoprim 3-oxide formation, however, other competitive P450 inhibitors has no obvious inhibition on the formation[1]. | ||||||||||||
| Name | Trimethoprim 3-oxide | ||||||||||||
| CAS | 27653-67-4 | ||||||||||||
| Formula | C14H18N4O4 | ||||||||||||
| Molar Mass | 306.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80. |