Tautomycetin_product_DataBase

Bioactivity	Tautomycetin is a potent and specifical PP1 inhibitor with the potential apoptosis-inducing activity. Tautomycetin inhibits purified PP1 and PP2A enzymes with IC50s of 1.6 nM and 62 nM, respectively. Tautomycetin is an antifungal antibiotic and has immunosuppressive effects in vivo. Tautomycetin can be used as a novel powerful tool to elucidate the physiological roles of PP1 in various biological events[1].
Invitro	Tautomycetin (100 ng/ml-10 μg/ml; 48 hours) has inhibitory effects on T cell proliferation in the murine mixed lymphocyte reaction (MLR) assays. The level of inhibition of MLR by TMC is 100-fold higher than that by CsA, and the IC50 of TMC is 7.8 nM[1].Tautomycetin (1 μg/ml) possesses immunosuppressive activity to inhibit the proliferation of T cells by inhibition of IL-2 secretion in human primary T cells[1].Tautomycetin (1 μg/ml; pretreated for 5 hours) blocks the phosphorylation of tyrosine residues on several specific cellular proteins in a dose- and time-dependent manner in T cells stimulated by immobilized OKT3 mAb[1].Tautomycetin (1 μg/ml; 5 hours) significantly inhibits the phosphorylation of Akt and BAD in a dose-dependent fashion inn Jurkat TAg cell line[1]. Western Blot Analysis[1] Cell Line:
Name	Tautomycetin
CAS	119757-73-2
Formula	C33H50O10
Molar Mass	606.74
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Solution, -20°C, 2 years

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