| Bioactivity | TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. |
| Invitro | PAR1 agonists stimulate concentration-dependent increases in [Ca2+]i and in the proportions of neurones. The maximal increase in [Ca2+]i above basal is detected in response to 10 μm TF-NH2(peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded[1]. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant[2]. |
| Name | TFLLR-NH2 |
| CAS | 197794-83-5 |
| Sequence | Thr-Phe-Leu-Leu-Arg-NH2 |
| Shortening | TFLLR-NH2 |
| Formula | C31H53N9O6 |
| Molar Mass | 647.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |