| Bioactivity | Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands[1]. | ||||||||||||
| Invitro | Stepronin (0.1-100 µM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium[1].Stepronin (10-100 µM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium[1].Stepronin (100 µM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Stepronin | ||||||||||||
| CAS | 72324-18-6 | ||||||||||||
| Formula | C10H11NO4S2 | ||||||||||||
| Molar Mass | 273.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yamada K, et al. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7. |
Stepronin
CAS: 72324-18-6 F: C10H11NO4S2 W: 273.33
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administrat
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