Staurosporine (GMP)_product_DataBase

Bioactivity	Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases[1][2][3][4][5].
Invitro	Staurosporine (GMP) (316 nM; 24 h) 诱导 RGC-5 细胞产生强健的神经突[1]。Staurosporine (GMP) (25 和 100 nM; 12 h) 诱导 SH-SY5Y 细胞分化，神经突突起增加并伴有显著的分支，减少细胞体尺寸[2]。Staurosporine (GMP) (20 nM) 诱导人成神经细胞瘤细胞系细胞分化[3]。Staurosporine (GMP) (5 nM) 可增强由 1 alpha,25 dihydroxyvitamin D3，dbc AMP，全反式-维甲酸 (RA)，放线菌素 D (Act D) 和其他化合物诱导的 HL-60-cell 细胞分化[4]。Staurosporine (GMP) (1 μM; 15 d) 诱导人成神经细胞瘤细胞分化[5]。
Name	Staurosporine (GMP)
CAS	62996-74-1
Formula	C28H26N4O3
Molar Mass	466.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ganapathy PS, et al. Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res. 2010 Jan;35(1):80-90. [2]. Pregi N, et al. Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2006 Feb;1763(2):238-46. [3]. Hajimu MORIOKA, et al. Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1. Agricultural and Biological Chemistry. 1985; 1959-1963. [4]. Okazaki T, et al. Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp Hematol. 1988 Jan;16(1):42-8. [5]. Yuste VJ, et al. The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. J Neurochem. 2002 Jan;80(1):126-39.

PeptideDB

Staurosporine (GMP)

CAS: 62996-74-1 F: C28H26N4O3 W: 466.53