| Bioactivity | Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4]. |
| Target | Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2). |
| Invitro | Sodium metatungstate hydrate (100 μM, 15 min) 在巨噬细胞中抑制 ATP 诱导的阴离子染料摄取和大通道[2]。Sodium metatungstate hydrate (100 μM, 8 h) 抑制 ATP 诱导的 P2X7 相关巨噬细胞焦亡[2]。Sodium metatungstate hydrate (100 μM, 8-24 h) 对巨噬细胞有很强的抗炎作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Sodium metatungstate hydrate 相关抗体: |
| In Vivo | Sodium metatungstate hydrate (5 mg/kg，腹腔注射，单次剂量) 在 CD39 基因敲除小鼠的腹膜和全身血流中显示出不同的细胞因子/趋化因子反应[3]。Sodium metatungstate hydrate (5 mg/kg，腹腔注射，一天一次，从第 0 天至第 4 天、第 7 天至第 11 天、第14 天至第 18 天) 联合抗 CD73 抗体和 AZD4635(HY-101980) 可降低多发性骨髓瘤 (MM) 小鼠的肿瘤负荷[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 314075-43-9 |
| Formula | 3Na2WO4.9WO3.xH2O |
| Molar Mass | 2968 (anhydrous basis) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wall M J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition [J]. Neuropharmacology, 2008, 55(7): 1251-1258. [2]. Pimenta-dos-Reis G, et al. POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages [J]. Purinergic Signalling, 2017, 13: 611-627. [3]. Csóka B, et al. CD39 improves survival in microbial sepsis by attenuating systemic inflammation [J]. The FASEB Journal, 2015, 29(1): 25. [4]. Yang R, et al. Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade [J]. Journal for immunotherapy of cancer, 2020, 8(1). |
Sodium metatungstate hydrate
CAS: 314075-43-9 F: 3Na2WO4.9WO3.xH2O W: 2968 (anhydrous basis)
Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26
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