| Bioactivity | Sanazole (AK-2123) is a hypoxic cell radiosensitizer that enhances radiation-induced DNA strand breaks and, in mouse fibroblastomas, enhances radiation-induced apoptosis by increasing nuclear condensation and fragmentation and increasing caspase-3 activity. Sanazole can be used in tumor therapy research[1][2]. |
| CAS | 104958-90-9 |
| Formula | C7H11N5O4 |
| Molar Mass | 229.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rajagopalan, et al. Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma. Journal of radiation research 44.4 (2003): 359-365. [2]. García-Angulo, et al. "Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II–III—preliminary positive results." International Journal of Radiation Oncology Biology Physics 22.3 (1992): 589-591. |