| Bioactivity | Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. | ||||||||||||
| Target | MAO A | ||||||||||||
| Invitro | Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki=6 μM and 186 μM, respectively)[1].Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2].Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3]. | ||||||||||||
| Name | Salsolidine | ||||||||||||
| CAS | 5784-74-7 | ||||||||||||
| Formula | C12H17NO2 | ||||||||||||
| Molar Mass | 207.27 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24. |