| Bioactivity | Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2]. |
| Invitro | Resiniferatoxin 导致通道开放时间延长和钙内流，从而导致对 TRPV1 阳性疼痛纤维或细胞体的细胞毒性[1]。 |
| In Vivo | Resiniferatoxin (2 μg/10 μl；鞘内注射到 T2/T3 间隙；冠状动脉闭塞后 4 周诱导大鼠心力衰竭) 显著和选择性地消除背角的传入标记物表达 (TRPV1 和降钙素基因相关肽) 并减少过度激活的 CSNA。Resiniferatoxin 显著逆转动作电位持续时间 (APD) 和 APD 交替的延长，降低室性心律失常的诱发性[2]。 |
| Name | Resiniferatoxin |
| CAS | 57444-62-9 |
| Formula | C37H40O9 |
| Molar Mass | 628.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11. [2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836. |