Pyridaben_product_DataBase

Bioactivity	Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[1][2].
Invitro	哒螨灵 (0-10 µM; 3 min) 选择性地抑制大鼠大脑亚线粒体颗粒中的复合物 I-III[1]。哒螨灵 (0-10 µM; 3 min) 以剂量依赖的方式导致大鼠大脑线粒体的呼吸控制明显下降 (IC50= 1.7 µM) (苹果酸-谷氨酸作为底物)[1]。哒螨灵 (0-10 µM; 3 min) 使 mtNOS 的功能活性明显下降 (以苹果酸-谷氨酸为底物)，但当底物为琥珀酸时则不会[1]。 Cell Viability Assay[1] Cell Line:
Name	Pyridaben
CAS	96489-71-3
Formula	C19H25ClN2OS
Molar Mass	364.93
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Gomez C,et al. Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. [2]. Namin HH, et al. Resistance to pyridaben in Canadian greenhouse populations of two-spotted spider mites, Tetranychus urticae (Koch). Pestic Biochem Physiol. 2020 Nov;170:104677.

PeptideDB