| Bioactivity | Prilocaine, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects[1][2]. | ||||||||||||
| Target | Na, K-ATPase | ||||||||||||
| Invitro | Prilocaine is more potent in inhibiting the Na,K-ATPase of plasma membranes of LM cells (transformed fibroblasts) at 37 ℃ (43.8 mM) than at 25 ℃ (28.2 mM)[2]. | ||||||||||||
| Name | Prilocaine | ||||||||||||
| CAS | 721-50-6 | ||||||||||||
| Formula | C13H20N2O | ||||||||||||
| Molar Mass | 220.31 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. M Mete, et al. Neurotoxic effects of local anesthetics on the mouse neuroblastoma NB2a cell line. Biotech Histochem. 2015 Apr;90(3):216-22. [2]. H Kutchai, et al. Effects of local anaesthetics on the activity of the Na,K-ATPase of canine renal medulla. Pharmacol Res. 2000 Jan;41(1):1-7. |