| Bioactivity | Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action[1][2][3]. |
| Invitro | The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states[2]. |
| In Vivo | Pancuronium (0.5 mg/kg; intravenous injection) abolishes the bradycardia induced both by injected acetylcholine (ACh) and by vagal nerve stimulation in guinea-pigs (250-300 g, male). At doses which produce 100% neuromuscular blockade, Pancuronium (0.04 mg/kg) potentiates vagally-induced bronchoconstriction[1]. Potentiation by Pancuronium of the effects of adrenergic nerve stimulation, is found in rat anococcygeus and vas deferens[3]. |
| Name | Pancuronium dibromide |
| CAS | 15500-66-0 |
| Formula | C35H60Br2N2O4 |
| Molar Mass | 732.67 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. A D Fryer, et al. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71. [2]. E Maestrone, et al. Extracellular pancuronium affects sodium current in chick embryo sensory neurons. Br J Pharmacol. 1994 Jan;111(1):283-7. [3]. J R Docherty, et al. A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat. Br J Pharmacol. 1980;71(1):225-33. |
Pancuronium dibromide
CAS: 15500-66-0 F: C35H60Br2N2O4 W: 732.67
Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscul
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.