| Bioactivity | PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis[1][2]. | ||||||
| Invitro | PTD-p65-P1 Peptide TFA (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM[1].PTD-p65-P1 Peptide TFA (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation[1].PTD-p65-P1 Peptide TFA (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%[1].PTD-p65-P1 Peptide TFA (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF[1].PTD-p65-P1 Peptide TFA (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation[2]. Western Blot Analysis[1] Cell Line: | ||||||
| Name | PTD-p65-P1 Peptide TFA | ||||||
| Shortening | DRQIKIWFQNRRMKWKKQLRRPSDRELSE | ||||||
| Formula | C170H276F3N57O46S | ||||||
| Molar Mass | 3943.52 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
PTD-p65-P1 Peptide TFA
CAS: F: C170H276F3N57O46S W: 3943.52
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p6
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