| Bioactivity | FL118 (10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin (HY-16560) analogue, is a potent and orally active survivin inhibitor. FL118 binds to oncoprotein DDX5 (p68) to dephosphorylates and degrades DDX5. FL118 can be used for the research of cancer[1][2]. | ||||||||||||
| Invitro | FL118 (0-200 nM; 24, 48 and 72 h ) inhibits the cell proliferation of ES-2 and SK-O-V3 cells[1].FL118 (0-100 nM; 0 and 24 h) inhibits the migration of ES-2 and SK-O-V3 cells[1].FL118 (0-100 nM; 48 h) affects the expression level of cytoglobin (CYGB)[1].FL118 (10 and 100 nM; 48 h) inhibits PI3K/AKT/mTOR signaling pathway, and affects the expression level of vimentin and E-cadherin in ovarian cancer cells[1].FL118 (0-100 nM; 6 and 24 h) dephosphorylates and degrades DDX5[2].FL118 (0-500 nM; 24, 48, 72 h) regulates survivin, McL-1, XIAP, cIAP2, c-MYc and mKras by regulating DDX5[2].FL118 (0-1 μM, 24 h) shows significant cytotoxic activity against the three tumor cell lines (A549, MDA-MB-231, and RM-1 cells)[3].FL118 (0-10 nM, 48 h) increases the production of PARP cleavage, and induces apoptosis in A549[3].FL118 (0-10 nM, 48 h) arrests A549 cells mainly at the G2/M phase[3]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | FL118 | ||||||||||||
| CAS | 135415-73-5 | ||||||||||||
| Formula | C21H16N2O6 | ||||||||||||
| Molar Mass | 392.36 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|