PNC-28 acetate_product_DataBase

Bioactivity	PNC-28 acetate is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 acetate can be used for pancreatic cancer research[1][2].
Invitro	PNC-28 (0-0.5 mg/mL) 可阻断致命的人胰腺癌细胞系的生长[2]。
In Vivo	PNC-28（2 mg/小鼠，SC 或 IP，持续 14 天）阻断体内 BMRPA1 的生长[1]。PNC-28（1-20 mg/小鼠，SC，持续 14 天）抑制 BMRPA1 Tuc3 肿瘤生长[1]。
Name	PNC-28 acetate
Sequence	Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly
Shortening	ETFSDLWKLLKKWKMRRNQFWVKVQRG
Formula	C164H255N47O37S.C2H4O2
Molar Mass	3569.18
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kelley A. Sookraj. QS304. Novel p53-Derived Peptide Induces Rapid Human Pancreatic Cancer Cell Death. 2008, 144(2), 1. [2]. Michl J, et al. PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. Int J Cancer. 2006 Oct 1;119(7):1577-85.

PeptideDB