| Bioactivity | PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively)[1]. PE154 can label β-amyloid plaques in histochemical analysis[2]. Storage: protect from light. |
| In Vivo | PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques[2]. Animal Model: |
| Name | PE154 |
| CAS | 1192750-33-6 |
| Formula | C35H35N5O4 |
| Molar Mass | 589.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Paul W Elsinghorst, et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6. [2]. Davide Brambilla, et al. Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine. 2011 Oct;7(5):521-40. |