| Bioactivity | Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3]. |
| Invitro | Oxythiamine (0-40 μM，2 天) 抑制 MIA PaCa-2 细胞的细胞活力 (IC50: 14.95 μM)[1]。Oxythiamine (0-500 μM，48 小时) 抑制 MIA PaCa-2 细胞中 14-3-3 蛋白 beta/alpha 的表达[1]。Oxythiamine (0.1-100 μM, 6-48 h) 抑制 A549 细胞增殖[3].Oxythiamine (0.1-100 μM, 24 h) 诱导 A549 细胞凋亡[3].Oxythiamine (0-20 μM) 抑制 Lewis 肺癌 (LLC) 细胞的侵袭和迁移 (IC50: 8.75 μM)[4]。 Cell Viability Assay[1] Cell Line: |
| Name | Oxythiamine |
| CAS | 136-16-3 |
| Formula | C12H16N3O2S |
| Molar Mass | 266.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Oxythiamine
CAS: 136-16-3 F: C12H16N3O2S W: 266.34
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and ind
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