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Oseltamivir

Bioactivity Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively[1].
In Vivo Oseltamivir (20 mg/kg/天,口服,每天两次,持续 10 天) 可预防 H1N1pdm 病毒感染小鼠的死亡[2]。Oseltamivir (10 mg/kg/天,口服灌胃,5天) 联合 Amantadine (HY-B0402) (15或30 mg/kg) 对小鼠 H5N1流感病毒感染的保护效果优于单一疗法[3] 。Oseltamivir还可与 Ribavirin (HY-B0434), 或 Favipiravir (HY-14768), 或Peramivir (HY-17015A) 一起用于预防小鼠流感病毒感染[4][5]。
Name Oseltamivir
CAS 196618-13-0
Formula C16H28N2O4
Molar Mass 312.40
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Reference [1]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [2]. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. [3]. Ilyushina NA, et al. Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir Ther. 2007;12(3):363-70. [4]. Ilyushina NA, et al. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97. [5]. Smee DF, et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44.

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