Metioprim_product_DataBase

Bioactivity	Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].
Invitro	Metioprim 对部分厌氧菌有抑制作用，平均 MIC 值为 3.2 μg/mL[1]。Metioprim (0-1.0 μM;0-8 h) 抑制细菌生长动力学，抑制大肠杆菌的 MIC 值为 0.7 μg/mL[2]。
In Vivo	Metioprim (5 mg/kg or 10 mg/kg; 静脉注射; 单剂量) 在羊中的消除半衰期比猪的短 (23 min vs 169 min)，它的主要代谢产物为蛋氨酸亚砜和甲氧磷磺酸[3]。药代动力学分析[1]Animal
Name	Metioprim
CAS	68902-57-8
Formula	C14H18N4O2S
Molar Mass	306.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. [2]. Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61. [3]. Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4.

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