| Bioactivity | L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite[1]. | ||||||||||||
| Invitro | L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM[1].L 888607 has some affinity for the human DP receptor with a Ki value of 211 nM[1].L 888607 displays a relatively high selectivity for CRTH2 receptor[1].L 888607 has agonistic activity on recombinant and endogenously expressed CRTH2 receptor with an EC50 value of 0.4 nM[1].L 888607(100 nM, 20 min) stimulates eosinophil chemotaxis[1]. Immunofluorescence[1] Cell Line: | ||||||||||||
| In Vivo | L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo[1]. Animal Model: | ||||||||||||
| Name | L 888607 | ||||||||||||
| CAS | 860033-06-3 | ||||||||||||
| Formula | C19H15ClFNO2S | ||||||||||||
| Molar Mass | 375.84 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gervais FG, Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. |
L 888607
CAS: 860033-06-3 F: C19H15ClFNO2S W: 375.84
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2
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