| Bioactivity | L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2]. | ||||||||||||
| Target | Ki: 26 nM (NPY5-R). | ||||||||||||
| Invitro | L 152804 displays > 300-fold selectivity over hY1, hY2, and hY4 receptors[1]. | ||||||||||||
| Name | L 152804 | ||||||||||||
| CAS | 6508-43-6 | ||||||||||||
| Formula | C23H26O4 | ||||||||||||
| Molar Mass | 366.45 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. [2]. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14. |