| Bioactivity | BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2]. | ||||||||||||
| Target | Ki: 3.3 nM (Neuropeptide Y1 receptor)IC50: 5.9 nM (hY1) | ||||||||||||
| Name | BMS-193885 | ||||||||||||
| CAS | 186185-03-5 | ||||||||||||
| Formula | C33H42N4O6 | ||||||||||||
| Molar Mass | 590.71 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32. [2]. Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82. |
BMS-193885
CAS: 186185-03-5 F: C33H42N4O6 W: 590.71
BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3
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