| Bioactivity | Isonixin (Isonixine) is a non-steroidal compound. Isonixin can be used for the research of pain and inflammation[1][2][3][4]. |
| In Vivo | Isonixine potentiates hexobarbital sleep time, reduces motor activity, antagonizes cardiazol-induced convulsions, causes hyperthermia, and inhibits tremorine-induced trembling in mice[1]. Isonixine (p.o.) showes a 3.15 h half-life of absorption and rapidly absorbs in a gastro-intestinal tract[2]. Isonixine (i.v., intragastrically and intraduodenally) mainly excrets via urine, and isonixine can be eliminated by urine within 50 hours[3]. Isonixine (2000 mg/kg; p.o. once daily for 6 months) presents some mild toxic effects and induces no gastrointestinal lesion in male rabbits and rats[4]. |
| Name | Isonixin |
| CAS | 57021-61-1 |
| Formula | C14H14N2O2 |
| Molar Mass | 242.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mitjavila MT, Martorell M. Algunos efectos de la isonixina sobre el sistema nervioso central [Various effects of isonixine on the central nervous system]. Arch Farmacol Toxicol. 1979 Dec;5(3):183-4. [2]. Carrera G, et al. Studies of absorption, distribution and excretion of 2,6-xylidide of 2-pyridone-3-carboxylic acid (isonixine). Arzneimittelforschung. 1979;29(9):1401-4. [3]. Carrera G, et al. Etude pharmacocinétique de l'isonixine [Pharmacokinetic study of isonixine]. Arch Farmacol Toxicol. 1978 Apr;4(1):111-2. [4]. Mitjavila MT, et al. Toxicological investigations of isonixine. Arzneimittelforschung. 1977 Jul;27(7):1460-4. |