| Bioactivity | Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2]. | |||||||||
| Invitro | Isoflupredone acetate (10-4, 10-7, or 10-10 M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7 M and 10-10 M) than the high concentration (10-4 M)[1]. | |||||||||
| In Vivo | Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275)[2]. Animal Model: | |||||||||
| Name | Isoflupredone acetate | |||||||||
| CAS | 338-98-7 | |||||||||
| Formula | C23H29FO6 | |||||||||
| Molar Mass | 420.47 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Trahan RA, et al. In vitro effects of three equimolar concentrations of methylprednisolone acetate, triamcinolone acetonide, and isoflupredone acetate on equine articular tissue cocultures in an inflammatory environment. Am J Vet Res. 2018 Sep;79(9):933-940. [2]. Hewson J, et al. Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia. Am J Vet Res. 2011 Dec;72(12):1613-21. |
Isoflupredone acetate
CAS: 338-98-7 F: C23H29FO6 W: 420.47
Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for resear
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