Bioactivity | Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases[1]. |
Target | IC50: Cap-dependent endonuclease |
Invitro | Influenza virus-IN-7 (Example 16) 在 MDCK 细胞中显示出对流感 A/Weiss/43(H1N1) 病毒的抗病毒活性,EC50 为 1000 nM)[1]。 |
In Vivo | Influenza virus-IN-7 (Example 16; 5 mg/kg; i.g.; twice daily for 5 days) 可提高 WSN/33 (H1N1) 感染小鼠模型的存活率[1]。 Animal Model: |
Name | Influenza virus-IN-7 |
CAS | 2703046-92-6 |
Formula | C29H26F2N4O7S |
Molar Mass | 612.60 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Wang Shen, et al. Polycyclic pyridopyridazine amide oxime-containing carbocyclic derivatives and uses thereof. Patent CN114315827A. |