H-9 Dihydrochloride_product_DataBase

Bioactivity	H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
Invitro	H-9 Dihydrochloride significantly inhibits A431 cells[1].H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases[1].
In Vivo	H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration[2].
Name	H-9 Dihydrochloride
CAS	116700-36-8
Formula	C11H15Cl2N3O2S
Molar Mass	324.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6. [2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8. [3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7.

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