| Bioactivity | GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. | ||||||||||||
| Target | pIC50: 4.9 (PCAF/GCN5). | ||||||||||||
| Invitro | GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9. GSK4028 also demonstrates potency toward BRD4 BD1 and BRD9 inTR-FRET assay with pIC50s of <4.3 and 4.5±0.13, respectively[1]. | ||||||||||||
| Name | GSK4028 | ||||||||||||
| CAS | 2079886-19-2 | ||||||||||||
| Formula | C17H21BrN4O | ||||||||||||
| Molar Mass | 377.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Humphreys PG, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60(2):695-709. |
GSK4028
CAS: 2079886-19-2 F: C17H21BrN4O W: 377.28
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of G
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.