| Bioactivity | Forskolin (Coleonol) (GMP) is Forskolin (HY-15371) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Forskolin is a potent adenylate cyclase activator and inducer of intracellular cAMP formation[1]. |
| Invitro | Forskolin (GMP) (10 μM, 21 days) transdifferentiates mouse fibroblasts to neurons, determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells induced by Ascl1[1].Forskolin (GMP) (25 μM, in hHPC maturation medium) induces hCiPS-cell-derived hHPCs to differentiate into mature hepatocytes (the detailed method refers to the reference)[2].Forskolin (GMP) (10 μM, during 5-15 days) induces human fibroblasts (HFF) reprogramming into functional cardiomyocytes[3].Forskolin (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells together with RepSox (GMP) (HY-13012G)[4].Forskolin (GMP) (10 μM, during 2-4 days) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC)[6]. |
| Name | Forskolin (GMP) |
| CAS | 66575-29-9 |
| Formula | C22H34O7 |
| Molar Mass | 410.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015;17(2):195-203. [2]. Guan J et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022;605(7909):325-331. [3]. Wang H, et al. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Rep. 2014 Mar 13;6(5):951- [4]. Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10(5):1505-1521. [5]. Zhao J, et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat Med. 2022 Feb;28(2):272-282. |
Forskolin (GMP)
CAS: 66575-29-9 F: C22H34O7 W: 410.50
Forskolin (Coleonol) (GMP) is Forskolin (HY-15371) produced by using GMP guidelines. GMP small molecules work appropriat
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