| Bioactivity | Erucin (ERU) is an isothiocyanate particularly abundant in arugula. Erucin shows anticancer, neuroprotective, and anti-inflammatory activities[1][2][3][4]. |
| Invitro | Erucin (ERU) (0-100 μM) releases H2S and inhibits cell viability in AsPC‐1 cells in a concentration-dependent manner[1].Erucin inhibits cell migration and altered the AsPC‐1 cell cycle, reducing G0/G1 phase and increasing G2/M and S phases[1].Erucin (30 μM, 72 h) induces AsPC‐1 cell apoptosis and inhibits cell migration[1].Erucin reduces levels of phosphorylated ERK1/2 in AsPC‐1 cells[1].Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC50 of 97.7 µM in A549 cells[2]. Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 µM, and increases p53 and p21 protein expression in A549 cells[2].Erucin decreases LPS-induced production of NO, prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-1β in RAW 264.7 cells[3].Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in RAW 264.7 cells[3].Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells[3]. Cell Viability Assay[1] Cell Line: |
| In Vivo | Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation[3].Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects[4]. Animal Model: |
| Name | Erucin |
| CAS | 4430-36-8 |
| Formula | C6H11NS2 |
| Molar Mass | 161.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Valentina Citi, et al. Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1). Phytother Res. 2019 Mar;33(3):845-855. [2]. A. Melchini, et al. Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells. Food Chem Toxicol. 2009 Jul;47(7):1430-6. [3]. Han Jin Cho, et al. Erucin exerts anti-inflammatory properties in murine macrophages and mouse skin: possible mediation through the inhibition of NFκB signaling. Int J Mol Sci. 2013 Oct 15;14(10):20564-77. [4]. Fabiana Morroni, et al. Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease. J Agric Food Chem. 2018 Jan 31;66(4):856-865. |