| Bioactivity | Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1]. | ||||||||||||
| Invitro | CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1].CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1].CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1]. | ||||||||||||
| Name | Dithiodipropionic acid | ||||||||||||
| CAS | 1119-62-6 | ||||||||||||
| Formula | C6H10O4S2 | ||||||||||||
| Molar Mass | 210.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir. |
Dithiodipropionic acid
CAS: 1119-62-6 F: C6H10O4S2 W: 210.26
Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL
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