| Bioactivity | Diloxanide furoate is the prodrug of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers[1]. | ||||||||||||
| Invitro | Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively[2]. | ||||||||||||
| In Vivo | Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2]. Animal Model: | ||||||||||||
| Name | Diloxanide furoate | ||||||||||||
| CAS | 3736-81-0 | ||||||||||||
| Formula | C14H11Cl2NO4 | ||||||||||||
| Molar Mass | 328.15 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. VA CLASSIFICATION. Diloxanide (Systemic) [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3. |
Diloxanide furoate
CAS: 3736-81-0 F: C14H11Cl2NO4 W: 328.15
Diloxanide furoate is the prodrug of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent a
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This product is for research use only, not for human use. We do not sell to patients.