| Bioactivity | Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases[1].[2].. |
| Target | IC50: 43μM in BV2 microglial cells |
| Invitro | Chlorpheniramine has an inhibitory effects with an value of IC50 is 43μM on proton currents in BV2 microglial cells[1].. Cell Viability Assay Cell Line: |
| In Vivo | Chloropheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) enhances white blood cells in the peripheral blood[2].. Animal Model: |
| Name | Chlorpheniramine |
| CAS | 132-22-9 |
| Formula | C16H19ClN2 |
| Molar Mass | 274.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128. [2]. Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35(12):2183-9. |