| Bioactivity | CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1]. | ||||||||||||
| Target | IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3) | ||||||||||||
| Invitro | CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs)[1]. CM10 induces a cellular/nuclear swelling necroptotic phenotype[1]. | ||||||||||||
| Name | CM10 | ||||||||||||
| CAS | 692269-09-3 | ||||||||||||
| Formula | C20H23N3O | ||||||||||||
| Molar Mass | 321.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. |