| Bioactivity | Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[1][2][3][4][5]. | ||||||||||||
| Invitro | Azilsartan (0-200 μM, 0-72 h) decreases the viability of HepG2 cells[5].Azilsartan (100 μM, 24 h) induces apoptosis in HepG2 cells[5].Azilsartan inhibits the specific binding of 125I-Sar1-Ile8-AII to human angiotensin type 1 receptors with an IC50 of 2.6 nM[3].Azilsartan potently inhibits aortic endothelial and vascular cell proliferation in the absence of exogenous Ang II supplementation[5].Azilsartan enhances adipogenesis and exerted greater effects than Valsartan (HY-18204) on expression of genes encoding peroxisome proliferator-activated receptor-α (PPARα), PPARδ, leptin, adipsin, and adiponectin[1]. Cell Proliferation Assay[5] Cell Line: | ||||||||||||
| Name | Azilsartan | ||||||||||||
| CAS | 147403-03-0 | ||||||||||||
| Formula | C25H20N4O5 | ||||||||||||
| Molar Mass | 456.45 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Azilsartan
CAS: 147403-03-0 F: C25H20N4O5 W: 456.45
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist
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