| Bioactivity | Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR[1]. |
| Target | IC50: 0.18 μM (T. californica nAChR), 22 μM (Human α7 nAChR), 63 μM (L. stagnalis AChBP), 230 μM (A. californica AChBP) |
| Name | Azemiopsin |
| CAS | 1391936-86-9 |
| Sequence | Asp-Asn-Trp-Trp-Pro-Lys-Pro-Pro-His-Gln-Gly-Pro-Arg-Pro-Pro-Arg-Pro-Arg-Pro-Lys-Pro |
| Shortening | DNWWPKPPHQGPRPPRPRPKP |
| Formula | C118H174N38O26 |
| Molar Mass | 2540.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Utkin YN, et al. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem. 2012 Aug 3;287(32):27079-86. |
Azemiopsin
CAS: 1391936-86-9 F: C118H174N38O26 W: 2540.88
Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. c
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