Apoptosis inducer 20_product_DataBase

Bioactivity	Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents[1].
Invitro	Apoptosis inducer 20 抑制不同癌细胞系的细胞生长活性。最敏感的细胞系是黑色素瘤细胞系 MelMet5，紧随其后的是 HeLa。[1]。Apoptosis inducer 20 (100 nM, 24 h) 导致 G2/M 细胞周期阻滞，并通过 caspase 3/7 激活诱导细胞凋亡[1]。活性磺胺类化合物对 HeLa, MCF7, BT-474, MDA-MB468, MES-SA, HT-1080, MelMet5, A375、WM-1366 和 Caki1 癌细胞的抗增殖 IC50 值[1]药代动力学分析[1]
Formula	C20H21N3O5S
Molar Mass	415.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fuentes-Martín R, et al. Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents[J]. Eur J Med Chem. 2024 Sep 5;275:116617.

PeptideDB