| Bioactivity | Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2]. | ||||||
| Invitro | Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood[1]. Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling[2].Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes[2]. | ||||||
| Name | Alamandine | ||||||
| CAS | 1176306-10-7 | ||||||
| Sequence | Ala-Arg-Val-Tyr-Ile-His-Pro | ||||||
| Shortening | ARVYIHP | ||||||
| Formula | C40H62N12O9 | ||||||
| Molar Mass | 855.00 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Alamandine
CAS: 1176306-10-7 F: C40H62N12O9 W: 855.00
Alamandine, a member of the renin-angiotensin system(RAS), a vasoactive peptide, is an endogenous ligand of the G protei
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