| Bioactivity | AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2]. | |||||||||
| Target | IC50: 13 nM (amidase) | |||||||||
| Invitro | AM 374 (0-9 nM) 抑制 N18TG2 细胞中 anandamide 分解[1]。 | |||||||||
| In Vivo | AM 374 (20 μg；心室内注射，1 次) 对 FR5 杠杆按压无影响，但与 anandamide (腹腔注射) 共同使用时减少杠杆按压[2]。 Animal Model: | |||||||||
| Name | AM 374 | |||||||||
| CAS | 86855-26-7 | |||||||||
| Formula | C16H33FO2S | |||||||||
| Molar Mass | 308.50 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21. [2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11. |