| Bioactivity | AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1]. |
| Target | ARE |
| Invitro | AI-3 (0.1, 0.3, 1, 3.2, 10, 32 µM; 12, 24 h) 在 IMR-32 细胞中以剂量依赖方式增加 NQO1 的转录水平和蛋白质表达水平[1] .AI-3 (10 µM; 2-24 h) 诱导 GSH 合成从 4 小时开始到 24 小时[1]。AI-3 在 IMR-32 细胞中的生物活性需要 Nrf2 和 PI3K的参与[1]。 Western Blot Analysis[1] Cell Line: |
| Name | AI-3 |
| CAS | 882288-28-0 |
| Formula | C11H13ClO3S2 |
| Molar Mass | 292.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang R, et al. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol. 2013 Aug 16;8(8):1764-74. |