| Bioactivity | ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells[1]. |
| Invitro | ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) [1].ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration[1].ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility[1].ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | ADG-2e |
| CAS | 2419951-75-8 |
| Formula | C42H67N11O4 |
| Molar Mass | 790.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |