| Bioactivity | AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research[1]. | ||||||||||||
| Invitro | AChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM[1]. | ||||||||||||
| Name | AChE/BChE-IN-10 | ||||||||||||
| Formula | C26H30N2O2 | ||||||||||||
| Molar Mass | 402.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761. |